It is appealing to consider hybrids of neural-network learning algorithms with evolutionary search procedures, simply because Nature has so successfully done so. In fact, computational models of learning and evolution offer theoretical biology new tools for addressing questions about Nature that have dogged that field since Darwin. The concern of this paper, however, is strictly artificial: Can hybrids of connectionist learning algorithms and genetic algorithms produce more efficient and effective algorithms than either technique applied in isolation? The paper begins with a survey of recent work (by us and others) that combines Holland's Genetic Algorithm (GA) with connectionist techniques and delineates some of the basic design problems these hybrids share. This analysis suggests the dangers of overly literal representations of the network on the genome (e.g., encoding each weight explicitly). A preliminary set of experiments that use the GA to find unusual but successful values for BP parameters (learning rate, momentum) are also reported. The focus of the report is a series of experiments that use the GA to explore the space of initial weight values, from which two different gradient techniques (conjugate gradient and back propagation) are then allowed to optimize. We find that use of the GA provides much greater confidence in the face of the stochastic variation that can plague gradient techniques, and can also allow training times to be reduced by as much as two orders of magnitude. Computational trade-offs between BP and the GA are considered, including discussion of a software facility that exploits the parallelism inherent in GA/BP hybrids. This evidence leads us to conclude that the GA's GLOBAL SAMPLING characteristics compliment connectionist LOCAL SEARCH techniques well, leading to efficient and reliable hybrids.